Anna's Picture

Medical Resident
Anatomical and Clinical Pathology
University of California, Irvine
E-mail: anna.shestakova (at) gmail (dot) com

I am an Anatomical and Clinical Pathology resident at the School of Medicine, University of California, Irvine.

Before that I was a postdoctoral fellow at the Department of Pathology, University of Utah. I worked in the Carl Wittwer's DNA Lab" and in the Jerry Kaplan's Lab.

I received my PhD from the Department of Biology, University of Utah, where I worked in the Markus Babst's lab (PhD Thesis).

Gain-of-Function EGLN1 Prolyl Hydroxylase (PHD2 D4E:C127S) in Combination with EPAS1 (HIF-2α) Polymorphism Lowers Hemoglobin Concentration in Tibetan Highlanders. Tashi T, Scott Reading N, Wuren T, Zhang X, Moore LG, Hu H, Tang F, Shestakova A, Lorenzo F, Burjanivova T, Koul P, Guchhait P, Wittwer CT, Julian CG, Shah B, Huff CD, Gordeuk VR, Prchal JT, Ge R. J Mol Med (Berl). 2017 (PubMed).
Evolutionary Selected Tibetan Variants of HIF Pathway and Risk of Lung Cancer. Lanikova L, Reading NS, Hu H, Tashi T, Burjanivova T, Shestakova A, Siwakoti B, Thakur BK, Pun CB, Sapkota A, Abdelaziz S, Feng BJ, Huff CD, Hashibe M, Prchal JT Oncotarget. 2017 (PubMed).
The Linker Region Plays a Regulatory Role in Assembly and Activity of the Vps4 AAA ATPase. Shestakova A, Curtiss M, Davies BA, Katzmann DJ, Babst M. Role of the linker region in the assembly and function of the Vps4 AAA ATPase. J Biol Chem. 2013 (PubMed).
Functional and Biochemical Studies of the VPS4 ATPASE in Saccharomyces Cerevisiae. A Shestakova. PhD Thesis. November 2011 (PDF).
Coordination of substrate binding and ATP hydrolysis in Vps4-mediated ESCRT-III disassembly. BA Davies, IF Azmi, J Payne, A Shestakova, BF Horazdovsky, M Babst, DJ Katzmann. Molecular biology of the cell 21 (19), 3396-3408 (PubMed).
Assembly of the AAA ATPase Vps4 on ESCRT-III. A Shestakova, A Hanono, S Drosner, M Curtiss, BA Davies, DJ Katzmann, M Babst Molecular biology of the cell 21 (6), 1059-1071. (PubMed)
Interaction of the conserved oligomeric Golgi complex with t-SNARE Syntaxin5a/Sed5 enhances intra-Golgi SNARE complex stability. Shestakova A, Suvorova E, Pavliv O, Khaidakova G, Lupashin V. J Cell Biol. 2007 Dec 17;179(6)1179-92. (PubMed)
Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis. Sun Y, Shestakova A, Hunt L, Sehgal S, Lupashin V, Storrie B. Mol Biol Cell. 2007 Oct;18(10):4129-42. (PubMed)
COG complex-mediated recycling of Golgi glycosyltransferases is essential for normal protein glycosylation. A Shestakova, S. Zolov and V. Lupashin. Traffic. 2006 Feb;7(2):191-204. (PubMed)

Updated: July, 2018